Dott. Domenico Massimo Ranieri
BIOGRAFIA PROFESSIONALE
Ordine dei Medici Bari re-iscrizione 7 Agosto 2020 n 16793
Iscrizione General Medical Council UK: Ottobre 1991 n 3574623
Member of the Royal College Obstetricians and Gynecologist (MRCOG) n 13577
Titoli di studio:
- Laurea in Medicina e Chirurgia, Università di Bari, Italia, novembre 1982 (110 con lode)
- Specialista in Ostetricia e Ginecologia, ottobre 1986 – Università di Bari, Italia, (50/50)
- MRCOG registrazione numero135996
- Diploma Family Planning
- Oral Contraception and IUD insertion DFFP (Margaret Pike Centre) marzo 1996
PRESENTE INCARICO
Dal 1 Gennaio 2021 Direttore Clinico Progenia CMRL
INCARICHI PRECEDENTI
Febbraio 2010 – Dicembre 2020 Vice Direttore Assisted Reproduction Gynecology Centre (ARGC)
Londra, Regno Unito
Agosto 1995- Gennaio 2010 Vice Direttore Assisted Conception Unit (CRGH) University College Hospital, Londra, Regno Unito
Febbraio 2004 Gennaio 2010 Senior Lecturer In Obstetrycs and Gynaecology University College Hospital, Londra, Regno Unito.(Incarico Accademico)
Febbraio 1997 – Gennaio 2004 Lecturer in Obstetric and Gynaecology University College Hospital, Londra, Regno Unito. (Incarico Accademico)
Agosto 95 – Febbraio 97 Ricercatore presso L’Asssited Conception Unit University College Hospital, Londra, Regno Unito
Mar 93 – Ago 95 Assistente Patologia Ostetrica e Ginecologica R Azienda Ospedaliera Universitaria Policlinico, Bari, Italia
Mar 92 – Feb 93 Ricercatore presso il L’Assisted Conception Unit University College Hospital, Londra, Regno Unito
Mar 92 – Feb 93 Assistente Unità di Endocrinologia Ginecologica e Medicina della Riproduzione University College Hospital, Londra, Regno Unito
Ottobre 89 – Febbraio 92 Assistente Patologia Ostetrica e Ginecologica R Azienda Ospedaliera Universitaria Policlinico, Bari, Italia
Novembre 86 – settembre 89 Assistente in Chirurgia IRCCS Oncologico, Bari, Italia
Ottobre 82 -Ottobre 86 Specializzazione In Ostetricia e Ginecologia
I Clinica Ostetrica e Ginecologica Policlinico Università di Bari, Italia
Esperienza nel campo della Medicina della Riproduzione
Il Professor Domenico Massimo Ranieri Specialista in Ostetricia e Ginecologia dopo alcuni anni di esercizio professionale presso la Clinica Ostetrica e Ginecologica del Policlinico di Bari, sentendo la necessità di approfondire le problematiche relative all’infertilità, decide dopo un periodo di formazione specifica nel settore, nel 1995 di accettare l’incarico di vicedirettore presso l’Assisted Conception Unit dello University college Hospital di Londra dove rimane fino al mese di Gennaio 2010. Durante questo periodo oltre a svolgere un’intensa attività clinica nel campo della fecondazione assistita, e a contribuire a livello pioneristico alla applicazione clinica delle tecniche di diagnosi reimpianto PGD e di PGS, si occupa anche della parte accademica divenendo Lecturer e poi Senior Lecturer in Obstetrics and Gynecology presso lo University College Hospital di Londra divenendo componente del board di insegnamento per il Subspeciality training programme in Medicina della Riproduzione. autore di pubblicazioni in numerose riviste prestigiose del settore quali Human Reproduction, Fertility & Sterility di cui diviene anche referee. Tale periodo coincide con l’incarico di Senior Lecturer in Ostetricia e Ginecologia presso la stessa
Nel 2010 decide di occuparsi delle problematiche relative all’impianto degli embrioni causa frequente di insuccessi ripetuti nella fecondazione assistita. Assume l’incarico di vicedirettore presso l’ARGC di Londra dove, in collaborazione con il Direttore del Centro, mette a punto un metodo innovativo per agevolare l’impianto embrionario. Questa tecnica innovativa consente all’Unita’ di ottenere risultati tra piu’alti a livello internazionale, con un live birth del 70% nelle pazienti fino a 35 anni provenienti da tutto il mondo, nonostante una prognosi riproduttiva complicata da numerosi precedenti cicli di fertilizzazione in vitro non coronati da successo.
Ha eseguito oltre 20000 cicli di fecondazione assistita con risultati di eccellenza durante la carriera nel Regno Unito, trattando anche numerose pazienti provenienti dall’Italia.
MAIN PUBLICATIONS
Jaroudi S, Kakourou G, Cawood S, Doshi A, Ranieri DM, Serhal , Joyce C. Harper JC, SenGupta SB. Expression profiling of DNA repair genes in human oocytes and blastocysts using microarrays. Human Reproduction; 10.1093/humrep/dep224.2009
Sahu B.,Ozturk O., Deo N., Fordham K., Ranieri M., Serhal P. Response to controlled ovarian stimulation and oocyte quality in women with myotonic distrophy J. Assist. Reprod. Genet.25:1, 2008
Sahu B, Ozturk O, Ranieri M, Serhal P. Comparison of oocyte quality and intracytoplasmic sperm injection outcome in women with isolated polycystic ovaries or polycystic ovarian syndrome.Arch Gynecol Obstet. 277(3):239-44.2008
Kakourou G, Dhanjal S, Mamas T, Gotts S, Doshi A, Fordham K, Serhal P, Ranieri DM, Delhanty JDA, Harper JC and SenGupta SB. Preimplantation genetic diagnosis for myotonic dystrophy type 1 in the UK. Neuromuscular Disorders 18: 131–136.2008
Mantzouratou A, Mania A, Fragouli E, Xanthopoulou L, Tashkandi S, Fordham K, Ranieri DM, Doshi A, Nuttall S, Harper JC, Serhal P, Delhanty JD. Variable aneuploidy mechanisms in embryos from couples with poor reproductive histories undergoing preimplantation genetic screening. Hum Reprod. 2007 Jul;22(7):1844-53
Muttukrishna S. McGarrigle,Wakim R., Khadum I., Ranieri D.M., Serhal P. Antral follicle count, anti-mullerian hormone and inhibin-B: predictors of ovarian response in assisted reproductive technology. BJOG. 2005;112:1-7
Serhal P.,Ranieri D.M.,Khadum I.,Wakim R.A. Cervical dilatation with hygroscopic rods prior to ovarian stimulation facilitates embryo transfer. Hum. Reprod .2003;18: 2618-2620.
Simopoulou M., Harper J.C., Fragouli E., Mantzouratou A., Speyer B.E., Serhal P., Ranieri D.M., Doshi A., Henderson J., Rodeck C.H., Delhanty J.D.A. Preimplantation Genetic Diagnosis of Chromosome Abnormalities: Implications from the Outcome for Couples with Chromosomal Rearrangements. Prenatal Diagnosis 2003; 23:652-662.
Meo F., Ranieri D.M., Kadhum I., Serhal P.F. Ovarian response and in vitro fertilization outcome in patients with reduced ovarian reserve stimulated with recombinant follicular stimulating hormone (rFSH) or human menopausal gonadotropin (hMG)after cessation of Gn RH analogue. Fertil. Steril.2002;77:630-632.
Ranieri D.M., Phopong P., Khadum I., Meo F., Davis C., Serhal P.F. Simultaneous evaluation of basal FSH and oestradiol response to GnRH analogue (F-G-test) allows effective drug regimen selection for IVF. Hum. Reprod. 2001; 16:673-675.
Phophong P., Ranieri D.M., Kadhum I., Meo F., Serhal P. Basal 17b-estradiol did not correlate with ovarian response and in vitro fertilization treatment outcome. Fertil.Steril. 2000; 74:1133-36.
Ranieri D.M., Serhal P.F. Ovarian Reserve: A simple mathematical problem? Hum.Reprod. 2000;15:1423-4.
Ranieri D.M., Kadhum I., Marinakis I., Davies M., Serhal P. Discontinued GnRH Analogue ovarian suppression combined with High dose gonadotrophin regimen for IVF patients with elevated basal FSH and abnormal response to the GnRH analogue stimulation test. Hum. Fertil. 1999; 2:196-197.
Ranieri D.M., Quinn F., Makhlouf A., Kadhum I., Ghutmi W., McGarrigle H., Davies M., Serhal P. Simultaneous evaluation of basal FSH and 17bOestradiol response to GnRH analogue Stimulation: a better predictor of ovarian reserve. Fertil. Steril. 1998;Vol 70:227-233.
Ranieri D.M. Is IVF/ICSI always the first step to treat couples with infertility due to retrograde ejaculation? Fertil. Steril. 1998; 69:1160-1161.
Serhal P.F., Ranieri D.M., Kinis A., Marchant S., Kadhum I. Oocyte morphology predicts outcome of intracytoplasmic sperm injection. Hum. Reprod. 1997;Vol. 12;1267-1270.
Ranieri D.M., Vicino M., Simonetti S., Cormio L., Selvaggi L. Successful establishment of pregnancy by superovulation and intrauterine insemination with sperm recovered by a modified Hotchkiss procedure from a patient with retrograde ejaculation. Fertil. Steril. 1995;Vol 64:1039-1042.
Ranieri D.M., Beckett V., Marchant S., Kinis A., Serhal P. Gamete intra-Fallopian transfer or in-vitro fertilisation after failed ovarian stimulation and intrauterine insemination in unexplained infertility. Human. Reprod. 1995;Vol 10:2023-2026.
(This article was selected to be abstracted in the Year Book of Infertility 1996 and the Year Book of Obstetrics and Gynecology 1996 dedicated to publishing excellence and edited by Mosby, Chicago).
Ranieri D.M., Sturdy J., Marchant S., Kinis A., Serhal P. Ovarian heterotopic pregnancy after IVF and contralateral tubal ectopic pregnancy after GIFT. Acta Europea Fertilitatis 1992;Vol 2, 35:243-24.
CHAPTER FOR BOOKS
Ranieri DM. “Clinical Assessment of the woman for assisted conception” in Good Clinical Practice in the assisted conception. Editors Serhal P, Overton C. Cambridge University Press.
INVITED LECTURES
The Lebanese International Fertility Summit, September 20th 2019
Hilton Beirut Metropolitan Palace “Luteal Phase Support in IVF”
The Lebanese International Fertility Summit, September 21th 2019 Hilton Beirut Metropolitan Palace
“Recurrent implantation failure: The Role of Immunology”
Clinical Aspects of IVF. MSc in Prenatal Genetics and Fetal Medicine-Module on Embryonic Development UCL, November 2008.
Fifth International AMN patient study day. PGD for patients with AMN (Lecture) 2008
Clinical Aspects of IVF. MSc in Prenatal Genetics and Fetal Medicine-Module on Embryonic Development UCL, November 2005.
The modern work up of the IVF Couple. The University College Hospital London Course in Reproductive Medicine, Sept 2004.
Ovum Donation. British Society for Paediatric and Adolescent Gynaecology, March 2004
Clinical Aspects of IVF. MSc in Prenatal Genetics and Fetal Medicine-Module on Embryonic Development UCL, October 2003.
Unexplained Infertility. The University College Hospital London Course in Reproductive Medicine, June 2003.
Clinical Aspects of PGD. 8th International UCL Preimplantation Genetic Diagnosis Workshop. June 2003.
IVF. 8th International UCL Preimplantation Genetic Diagnosis Workshop. June 2003.
Egg Donation in 2003. Keynote. 1st International Egg Donation Conference, Global Egg Donation Resource. London, UK, February 7-10 2003
Unexplained Infertility. The University College Hospital London 5thCourse in Reproductive Medicine, June 2002.
Clinical Aspects of PGD. 7th International UCL Preimplantation Genetic Diagnosis Workshop. April 2002.
Unexplained Infertility. The University College Hospital London 4th course in reproductive Medicine, June 2001.
Progress in Infertility treatment. Probios, Brindisi, Italy, February 2002.
Unexplained Infertility. The University College Hospital London 3rd course in reproductive Medicine, June 2001.
Recent advances in In Vitro Fertilisation. 2nd Department of Obstetrics and Gynaecology, Bari, Italy, April 2001.
Management Of Unexplained Infertility. The University College Hospital London 2nd course in reproductive Medicine, June 2000.
Assessment of the Ovarian Reserve. Hammersmith Hospital, IVF Unit, May 1998.
ORAL PRESENTATION
Walker D., Adeaga S., Arnot M., Arthur I.,Biljan M., Ranieri M., Hamill-Keyas J. et al. (Collaborative Study). Use of subcutaneous FSH preparation for superovulation: comparison with intramuscular Metrodin. 9th Annual Meeting of the ESHRE, Thessaloniki, 1993. Hum Reprod.8 Supplement 1, 186-187 June 1993
Ranieri D.M., Vicino M., Simonetti S., Selvaggi L. Donor egg pregnancy after transmyometrial intra-endometrial stroma embryo-transfer. The Italian Fertility Society XVII National Meeting, Genoa December 1994.
Vicino M., Ranieri D.M., Simonetti S., Selvaggi L. Relationship between concentration of normal sperms after Mini-Percoll preparation and IVF results in male infertility. The Italian Fertility Society XVII National Meeting, Genoa, December 1994.
Serhal P., Ranieri D.M., Schulte A.C.,Kinis A., Marchant S. Morphology of the Oocytes as a predictor of the success rate with intracytoplasmic sperm injection. British Fertility Society Annual Meeting, Cardiff 1996.
Abou-Sleiman P.M., Harper J.C., Wells D., Apessos A., Piyamongkol W., Ioulianos A., Almeida P., Serhal P., Ranieri M.., Delhanty J.D.A. Preimplantation genetic diagnosis for five single gene disorders including Crouzon syndrome and neurofibromatosis type-2. 17th Annual Meeting of the ESHRE, Lausanne, 2001. Hum Reprod. 16, 51-52, 2001.
Ranieri D.M., Wakim R., Kadhum I., Serhal P. Lack of LH surge despite cessation of GnRH analogue administration. 18th Annual Meeting of the ESHRE, Vienna, 2002. Hum Reprod. 17, 73, 2002.
Serhal P., Ranieri D.M., Khadum I., Wakim R. The use of hygroscopic cervical rods (Dilapan-S TM) in patients with cervical stenosis undergoing in vitro fertilization. 58th Annual Meeting of the ASRM, Seattle, 2002, Fertil. Steril. 76, S11, 2002
POSTER PRESENTATION
GIFT and IVF in unexplained infertility after failed superovulation and intrauterine insemination. The BFS 2nd International Meeting, Glasgow, May 1994. Human Reproduction July 1994;Vol 9, Suppl 3:41.
Follicle stimulating hormone (pFSH) treatment for male factor inferitily with previous failed fertilization in vitro. The BFS 2nd International Meeting, Glasgow, May 1994. Human Reproduction, July 1994;Vol 9, Suppl 3;12.
Discontinued GnRH analogue ovarian suppression combined with high-dose gonadotrphin regimen for IVF patients with elevated basal FSH and abnormal response to the GnRH analogue stimulation test. The BFS Meeting Newcastle 1999. Hum Fertil 1999;2:196-197.
Comparison between HMG and recombinant-FSH for ovarian stimulation in patients undergoing IVF. 16th Annual Meeting of the ESHRE, Bologna 2000, Hum Reprod 2000.
Assessment of the uterine cavity by saline hystero-contrast-sonography before IVF. 18th Annual Meeting of the ESHRE, Vienna, 2002. Hum Reprod. 17, 165-6, 2002.
Do Serum Anti Mullerian Hormone and Inhibin B measurements increase the efficacy of G-test? The BFS Meeting Liverpool, Jan 2004.
Anti Mullerian Hormone and Inhibin B: Markers of Ovarian Stimulation Test? The BFS Meeting Liverpool, Jan 2004.
The Bishop score: a novel scoring system for ovarian reserve. IWH 3rd Annual Meeting 2007
Course of the first 2 families PGD For BRCA 1 in the UK. IWH 3rd Annual meeting 2007
Evidence for variable aneuploidy mechanism….Chromosome research vol15, Sup 1 p231 2007
